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The phrase "a serious problem that" is correct and usable in written English.
You can use it when introducing a significant issue or concern that requires attention or action.
Example: "There is a serious problem that needs to be addressed immediately to ensure the safety of our community."
Alternatives: "a critical issue that" or "a significant challenge that".
Exact(60)
School avoidance is a serious problem that can worsen rapidly.
He realized the lack of rural livelihoods was a serious problem that was going unaddressed.
Water scarcity is a serious problem that will be exacerbated by global climate change.
Pesticide residue in vegetables is a serious problem that has adverse effects on human health.
Peritoneal adhesion is a serious problem that develops after most abdominopelvic surgeries.
Another issue is reaching homeless female veterans, a serious problem that also affects the male population.
Fighting militancy and violence is a serious problem that must be confronted.
Resistance to the gravitational force is a serious problem that plants have had to solve to survive on land.
Make no mistake, the deficit is a serious problem that must be addressed in the medium term.
This, Lord Bingham conceded, was a serious problem that "might well" call for urgent attention by Parliament.
The interaction between implantable devices and EAS systems is a serious problem that can be minimized through appropriate facility design.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com