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The phrase "a serious problem of" is correct and usable in written English.
It can be used when discussing an issue that is significant or concerning in nature, often followed by a specific topic or area of concern.
Example: "The report highlighted a serious problem of pollution in the local river."
Alternatives: "a significant issue regarding" or "a major concern about".
Exact(60)
Teaching literature, therefore, involves a serious problem of translation.
Is it insensitive in a society with a serious problem of violence against women?
Mr Cable said: "Harriet Harman faces a serious problem of credibility.
"It comes down to a serious problem of life in the city," he says.
And there is a serious problem of internal regulation at the S.E.C.
But with all confessional books of this kind there is a serious problem of tone and intent.
"There is a serious problem of interests involved, and some people don't care, because it is state money".
China has a "serious problem of haphazard investment," he said, adding that peasants have suffered "widespread illegal appropriation of farmland".
Choosing judges in partisan elections, rather than through a system of merit selection, can create a serious problem of quality control.
He was put on war work, introduced to a serious problem of cracking of armour plating of tanks at electric arc welds, which he solved.
"It's not just that he hasn't delivered on any changes, it's that he hasn't publicly acknowledged that there is a serious problem of police abuse," said Morayef.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com