Essential revisions: A serious problem concerns the role of Notch signaling, which is not clearly established.
A serious problem concerns the role of Notch signaling, which is not clearly established.
The most serious problem concerning the large number of caregivers that consistently suffer from anxiety and depression is that this situation stems from the overwhelming responsibilities related to the role that they cover [ 12, 13].
Though the question of whether the data support a dual process theory of brain activity and whether moral thinking divides up in the way described is hotly debated, a larger and equally serious problem concerns the assumed opposition between emotional and rational thinking.
The most serious problem concerns the authors' intentions.
An even more serious problem concerns the vector of yellow fever, which for centuries was one of the great plagues of the world.
Another serious problem concerns the real or potential isolation of the less educated, disabled and pure citizens from the access to the increasingly complex and complicated services of electronic government, particularly from the access to its interactive part.
The third and most serious problem concerned the king's favourite, Piers Gaveston.
Karen BennetheWilson, the CQC's head of hospital inspection, said: "Our inspection has identified a number of serious problems concerning patient safety and the quality of care that needed immediate attention.
In proceeding this way, however, we would have to face serious problems concerning purely logical propositions, i.e., propositions all of whose parts are purely logical ideas.
