The phrase "a serious negative effect" is correct and usable in written English.
You can use it when referring to a detrimental outcome of a particular situation or event. For example, "The introduction of new technology had a serious negative effect on the economy."
Our lack of retaliation was seen in the West as very smart, but in the Arab world it had a serious negative effect on Israel's deterrence posture.
According to the existing literature, overwork may have a serious negative effect on physical and mental health, job satisfaction, and even the family relationship of employed workers (Jacobs and Gerson 2004; Golden and Barbara 2006).
Late payments and missing payments altogether can have a serious negative effect on your credit score.
This will have a serious, negative effect not only on the robustness of the innovation sector per se, but on our country's leadership in medical technology and its ability to use these technologies to address our health care challenges.
Although the use of "hard" chemical insecticides has provided some control, their toxicity to non-target animals and humans poses a serious negative effect on the environment [1], [2], [4], [5].
Accordingly, impairments in ToM can have a serious negative effect on interpersonal relationships, employment, and social interactions [ 3, 4].
The monitors sometimes had to console people through periods of anxiety, Dr. Griffiths said, but these were generally short-lived, and none of the people reported any serious negative effects.
In order to enhance the stability of the lipase, three-step methanolysis was adopted, however, glycerol, as one of the products was easy to adsorb on the surface of lipase resulting in serious negative effect on the enzymatic activity.
Mental disorders have serious negative effect on survival, and when present with chronic diseases as co-morbid condition, serious mental disorders may reduce life expectancy by about 20 years [ 4].
