The phrase "a serious issue when" is correct and usable in written English.
It can be used to introduce a situation or condition that is problematic or concerning in a specific context.
Example: "There is a serious issue when the data is not accurately reported, as it can lead to significant misunderstandings."
Alternatives: "a critical problem when" or "a significant concern when".
"It's a serious issue when you're dealing with advertisers," he said.
The critics agree that contamination can be a serious issue when using polymerase chain reaction technology.
This would project a serious issue when other universities in the region have proven to be more attractive, in terms of student's achievement, tuition fee and personalized assistance.
Since the surfactants invariably present residual surfactants or organic additives attached to the surfaces of products can block the active sites, it is a serious issue when considering applications in gas sensing or catalysis.
This article describes the various problems drivers have with heat – I never thought about it, but dehydration and heat exhaustion can be a serious issue when you're driving a hot car in the sun for several hours while wearing protective gear, a helmet, and so on.
For residents and activists, it's a serious issue when the city's poorest, including children, are made to live without running water in their home.
n Adult who chooses not to become familiar with computers 1995 Feb 27 LynNell Hancock et al Newsweek 53/1 These aging choose-nots become a more serious issue when they are teachers in schools.
This would be a more serious issue when lower-density markers are used for GEBV predictions.
Amanda Capes-Davis, based in Sydney, Australia, and chair of the International Cell Line Authentication Committee, agrees that mislabeling of cell samples in transcriptomic studies is a serious issue, particularly when using so-called cell lines, which have been grown in lab dishes for extended periods, even years to decades.
However, a serious issue arises when RhB is used for polymer-based devices such as poly(dimethylsiloxane) (PDMS), commonly used for microfluidic applications.
Catalytic electrode poisoning is one of the most serious issues when noble metals are involved.
