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The phrase "a serious failure" is correct and usable in written English.
It can be used to describe a significant or critical lack of success in a particular context, such as a project, plan, or system.
Example: "The project's outcome was deemed a serious failure, leading to a complete reevaluation of our strategy."
Alternatives: "a major setback" or "a significant shortcoming."
Exact(59)
The report also details a serious failure of statecraft.
Not doing so will be a serious failure of his progressive project.
This was due to "a serious failure of training", common across the NHS at that time.
There was a "serious failure" of its duties by the trust's board of directors.
That was a serious failure that is being investigated [by the ombudsman].
The regulator said there had been "serious editorial misjudgments" compounded by a "serious failure of its compliance process".
"And on the other hand, we have a serious failure of the state to provide adequate care".
This was a serious failure, right at the root of the evidence-based, problem-solving philosophy of the programme.
In a scathing assessment of the trust's board of directors, Francis accused it of "a serious failure" of its duties.
"All of these add up to a serious failure in exercising judgment, responsibility and prudence," the report said.
Whether that is a failure of American imagination or politics is unclear, but a serious failure it remains.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com