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The phrase "a serious drawback for" is correct and usable in written English.
It can be used when discussing a significant disadvantage or negative aspect related to a particular subject or situation.
Example: "The high cost of living in the city is a serious drawback for many potential residents."
Alternatives: "a major disadvantage for" or "a significant limitation for".
Exact(19)
Workability could be a serious drawback for a fresh fly ash-based geopolymer due to its high viscosity.
While The Heroic Life of George Gissing will delight his admirers, one must acknowledge a serious drawback: for a book this expensive it ought to have included photographs.
Objective: Sialography is commonly used for the diagnosis of Sjögren's syndrome, although its invasive nature is often regarded as a serious drawback for routine usage.
Although this is undoubtedly beneficial in daily life, it is a serious drawback for neuroscientists: because much brain activity does not translate directly into behaviour, its function is difficult to determine.
However, most of the recent investigations into the design and optimization of biomass supply chains have focused on an economic point of view, sidelining other dimensions of sustainability, which represents a serious drawback for this kind of work.
The resulting heat may be a mere inconvenience for users of high-end laptops, who risk burning their hands or thighs, but it is a serious drawback for untethered devices, where it shortens battery life and increasingly for data centres as well, as Google again shows.Cool chipsThe firm's servers are densely packed to save space and to allow them to communicate rapidly.
Similar(41)
A serious drawback of the flux estimation method in current use is that it does not produce confidence limits for the estimated fluxes.
A serious drawback of thermoelectrics is poor efficiency [28].
The neglect of non-local electron correlation effects is a serious drawback of common DFT methods.
However, the number is still high and therefore is a serious drawback of the PPM algorithm.
Such incompleteness of clustering is a serious drawback of the existing algorithms.
More suggestions(16)
a serious deficiency for
a serious weakness for
a considerable drawback for
a serious flaw for
a serious difficulty for
a tremendous drawback for
a major drawback for
a serious handicap for
a grave drawback for
a serious problem for
a serious failing for
a serious thing for
a crucial drawback for
a serious contender for
a serious time for
a serious moment for
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com