The phrase "a serious concern when" is correct and usable in written English.
It can be used to introduce a situation or condition that raises significant worry or anxiety.
Example: "There is a serious concern when the safety protocols are not followed during the experiment."
Alternatives: "a significant issue when" or "a major worry when".
This suggests that the allocation of a child's time has no substantial effect on the subsequent health status of her mother or father, so reverse causality is unlikely to be a serious concern when estimating the parameters in Eq. (1) of the main text.
Overweight zoo elephants, who tend to pack the pounds onto their rear ends, suffer from cardiac arrest, arthritis and infertility -- conditions that pose a serious concern when many African elephant populations are endangered.
The simplicity of the architecture makes the systems far more energy efficient, which is a pretty serious concern when you're a company like Facebook building a new data center.
Mr. O'Rourke, however added that "I do think now that we are going to have to consider if there is any way to tighten this up because it is a matter of serious concern when you're talking about an elected official who may not be a citizen".
"It's a matter of serious concern when he loses contact with his family and friends," the organization's deputy director for Asia and Pacific programs, Catherine Baber, said in a telephone interview from London.
Another serious concern when dealing with a cyber school is the possible lack of social life for virtual students.
Fighting in the Syrian capital has also caused serious concern – when rebels entered the Old City in 2012, the government shelled it.
He acknowledged that "there was some serious concern when they really wanted to push through the door to participate in that meeting".
Such gaps raise serious concern when adherence to the restrictive transfusion guidelines is broadly promulgated in the current clinical literature, emphasizing a broad endorsement of the guideline.
We consider this as another benefit of using the Flexi ORF clones, since production level is a serious concern, particularly when a recombinant protein is synthesized in vitro.
