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The phrase "a serious case" is correct and usable in written English.
It can be used when referring to a situation or issue that is significant, urgent, or requires careful attention.
Example: "The doctor diagnosed her with a serious case of pneumonia that required immediate treatment."
Alternatives: "a critical situation" or "a grave matter."
Exact(60)
A serious case of cancer?
A serious case review was opened.
A serious case of rust.
Now that's a serious case.
This is a serious case.
You obviously can't mount a serious case.
A serious case review was also begun.
A serious case can be made for the Olympic bid.
It has a serious case of split personality.
"This is a serious case, the first of its kind.
Dani soon succumbs to a serious case of the blues.
More suggestions(18)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com