Sentence examples for a sequential trial from inspiring English sources

A sequential trial plan using a two-sample sequential Wilcoxon test developed by Skovlund and Walløe is therefore used.

Ideally, a sequential trial should have an a priori definition of clinically meaningful change on an interval scale.

The necessity for a special form of statistical analysis following a sequential trial is explained, and the consequences of early or late stopping on the analysis are investigated.

The authors in the current study used a sequential trial design with interim analyses approximately every 20 patients in order to reduce the number of patients exposed to "inferior" treatment through early study termination if treatment-related outcome differences emerged.

Please cite this paper as: Oppegaard K, Nesheim B, Istre O, Qvigstad E. Comparison of self-administered vaginal misoprostol versus placebo for cervical ripening prior to operative hysteroscopy using a sequential trial design.

A sequential trial plan using a two-sample sequential Wilcoxon test developed by Skovlund and Walløe was used in the current study to keep the number of women needed to reach a conclusion as low as possible.

In a significant proportion of patients no underlying diagnosis was established despite a sequential trials of treatment and extensive investigations.

The trial will be stopped if a difference is found in the complication rates using a significance level of 0.15% based on the O'Brien-Flemming boundaries for a group sequential trial.

The first approach, as pioneered by Emerson & Fleming (1990) and further clarified by Liu & Hall (1999), applies to a group sequential trial with one active treatment and one control arm that stops when conclusive evidence (for or against the efficacy of the treatment) is first observed.

Fluorescently labeled probes specific for ERG-related rearrangements involving the TMPRSS2-ERG fusion as well as TMPRSS2-ETV1 and TMPRSS2-ETV4 were used to assess samples for gene rearrangements indicative of malignancy under a design of sequential trial.

Drug development traditionally follows a sequential clinical trial paradigm to address specific objectives at each trial phase.