Exact(1)
This framework conceives successful change as one that arises from a sequential transformation of understanding among key individuals as to the purpose (object) of their work activities.
Similar(57)
This idea, also known as the retrograde hypothesis, has intuitive appeal and states that if the contemporary biosynthesis of compound "A" requires the sequential transformation of precursors "D," "C," and "B" through the corresponding enzymes, the final product "A" of a given metabolic route was the first compound used by the primordial heterotrophs (Fig. 8).
Indeed, the bulk for the oxygen requirement centers on the sequential transformation of lanosterol to cholesterol, involving several redox reactions.
The over-expression strain was constructed by sequential transformation of E. coli ER3081 (NEB) by pSYXS20-hpyAVM and then pAII17-hpyAVR.
This shows that there is sequential transformation of product 1 to the more polar 5,7- diene (product 2) and 7DHP, and the sole conversion of product 2 to 7DHP.
In addition to HPV, the sequential transformation of cervical squamous epithelium requires the acquisition of additional copies of chromosome arm 3q.
These authors were able to identify genes that are involved in the sequential transformation of normal to malignant plasma cells and thus can be useful in identifying the progression of MGUS to PCM.
AES consists of 40 sequential transformation steps composed of simple and basic operations such as table lookups, shifts, and XORs.
For instance, a needle puncture induced sequential transformation from a chondrocyte-like IVD to a fibrous degenerate IVD, and static compressive load, induced a decline in NCs together with sclerosis of the endplate [ 18, 20].
Patients with sequential transformation showed a non-significant trend towards worse overall and progression free survival compared to patients with simultaneous presentation of NLPHL and DLBCL (Additional file 2: Figure S1).
The past several decades have seen dramatic progress in understanding of pancreatic cancer pathogenesis, including identification of precursor lesions, sequential transformation from normal pancreatic tissue to invasive pancreatic cancer and corresponding signature genetic events, and the biological impact of these events on malignant behavior.
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