This idea, also known as the retrograde hypothesis, has intuitive appeal and states that if the contemporary biosynthesis of compound "A" requires the sequential transformation of precursors "D," "C," and "B" through the corresponding enzymes, the final product "A" of a given metabolic route was the first compound used by the primordial heterotrophs (Fig. 8).
For instance, a needle puncture induced sequential transformation from a chondrocyte-like IVD to a fibrous degenerate IVD, and static compressive load, induced a decline in NCs together with sclerosis of the endplate [ 18, 20].
Patients with sequential transformation showed a non-significant trend towards worse overall and progression free survival compared to patients with simultaneous presentation of NLPHL and DLBCL (Additional file 2: Figure S1).
A sequential phase transformation was observed and recorded by X-ray diffraction analysis, which involved N=N bond flipping and Fe‒ Obond bending.
Starting from a relatively less ordered, cheaper, and mass producible graphene oxide (GO), to this end, we herein describe a sequential chemical transformation to obtain a higher ordered crystalline and conjugated structure of the GO.
An over-expression E. coli strain was constructed by transforming E. coli ER3081 (NEB) with pSYX20-hpyAVM and pAII17-hpyAVR by sequential transformation (See Materials and Methods).
The simplest sequential transformation is retiming.
The past several decades have seen dramatic progress in understanding of pancreatic cancer pathogenesis, including identification of precursor lesions, sequential transformation from normal pancreatic tissue to invasive pancreatic cancer and corresponding signature genetic events, and the biological impact of these events on malignant behavior.
Indeed, the bulk for the oxygen requirement centers on the sequential transformation of lanosterol to cholesterol, involving several redox reactions.
AES consists of 40 sequential transformation steps composed of simple and basic operations such as table lookups, shifts, and XORs.
