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A sequential or a partially compulsory order mechanism for substrate binding has been reported for the FGAR-AT in various organisms, with Gln binding first followed by Mg-ATP and FGAR.
The first criterion guarantees a sequential or order-dependent matching because 3D domain swapping itself does not affect the sequential order of SSEs in a protein structure.
Therefore, the mechanism of substrate addition must either follow an ordered sequential or a preferred-ordered random sequential pathway, where acyl-ACP is most likely the first substrate to add to the enzyme (Km of acyl-ACP is much lower than Km of SAM).
Controlled delivery of drug at a constant rate, in a sequential order, or responsive to environment conditions has been pursued for a long time to enhance the efficacy of therapeutic molecules and to minimize side effects of highly potent drugs.
This suggests that these three STPKs are organized in a sequential order or a cascade and they work one after another to finally phosphorylate the GroES.
Blocks of trials were completed in a Sequential-Concurrent-Sequential order to minimize practice effects.
These spatial cues appear in blocks of trials with either a random or a sequential order.
Depending on the treatment protocol, different chemo-regimens are used in combination or in a sequential order.
The borough president's guidelines also say that addresses are "designed to maintain a sequential order".
These moments are represented on transparent surfaces that are assembled in a sequential order.
And you will cover these essential concepts in a sequential order that simulates the M&A process.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com