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The R allele is a normal functional version of the gene, whereas the X allele contains a sequence change that completely stops production of functional α-actinin-3 protein.
The R allele is a normal functional version of the gene, whereas the X allele contains a sequence change that completely stops production of functional α-actinin-3 protein [3].
However, since a sequence change in PTEN imply one remaining wild type allele, additional activating mutation in the same pathway may be beneficial for the tumor cells [41].
An editing site within the protein-coding region of an mRNA can result in a sequence change that may lead to an amino acid alteration in the protein.
The molecular basis of this innovation appears to be gene duplication followed by a sequence change that inhibits homodimerization (Fig. 5C), a process that conforms to one of the well-established "principles governing molecular evolution" [73].
It is the ability to correctly exclude a sequence change from the wild type if that change does not exist.
Similar(41)
Our study demonstrates how the HeT-A sequence changes much faster than previously reported resulting in at least nine different subfamilies most of which could actively contribute to telomere extension in Drosophila.
The server used the substitution matrix to describe the rate at which how one character in a sequence changes to other character over time [35].
To assure artifact-free transitions within a sequence, changes between gratings and plaids were implemented by a dynamical color table assignment method.
In bioinformatics and evolutionary biology, the substitution matrix like BLOSUM62 describes the rate where one character in a sequence changes to other character states over time.
Since GIs tend to change often (any time a sequence changes), we mapped GIs to their corresponding accessions where possible using an NCBI Toolkit command line tool id1_fetch (http://www.ncbi.nlm.nih.gov/IEB/ToolBox/CPP_DOC/lxr/source/src/app/id1_fetch/id1_fetch.cp).nih.gov/IEB/ToolBox/CPP_DOC/lxr/source/src/app/id1_fetch/id1_fetch.cp
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CEO of Professional Science Editing for Scientists @ prosciediting.com