Sentence examples for a separation of function from inspiring English sources
We have demonstrated that RB-KN is a separation of function mutant, which is useful in further studies of the anti-apoptotic function of RB.
The latter is not a novel conclusion, but it is obtained here with a "separation of function" mutant of BubR1 that is checkpoint proficient.
mad2-S92A is a "separation of function" allele: although mph1-kd and mad2Δ have defects in both checkpoint activation and maintenance, mad2-S92A ispecificallyly defective in maintenance.
Also of note, all of the organisms that contain an STK-bearing isoform also have one with a GLK motif, suggesting perhaps a separation of function in the two types of isoforms.
Additionally, our model argues that it might not be possible to identify a separation-of-function allele for Ku where NHEJ is fully functional and TRF2 binding is eliminated if the residues required for TRF2 binding completely overlap with those required for NHEJ.
The present studies revealed that a separation-of-function mutation of Swi3, which render cells sensitive specifically to CPT, also caused sister chromatid cohesion defects comparable to swi3 deletion mutants.
The E124A and R135A alleles retained tgs1 ∆ suppressor activity, thereby establishing a separation-of-function.
Our current data therefore identify the single amino acid change (V749A) in TEX11 as a separation-of-function mutation that disrupts chromosomal synapsis but not meiotic recombination.
When the wild-type copy of est4 was cloned, it was found to be a separation-of-function allele of the previously identified essential CDC13 gene and renamed cdc13 -2 (Nugent et al. 1996).
More definitive evidence for the involvement of HIM-3 in mediating cohesion will require a separation-of-function allele that disrupts SCC but not SC assembly or crossover recombination.
Earlier, we showed that this is a separation-of-function allele that shows a subset of DDK-associated phenotypes; dfp1-r35 cells are proficient for replication, but defective in response to alkylation damage (Dolan et al., 2010).
