Strengths of this study include a large sample size, a rigorously-defined ACS population, detailed FA analysis, the use of stable biomarker of tissue FA status, use of separate derivation and validation data sets, and a comprehensive examination of several metrics of model utility.
Their separate derivation from proteins of either high or low thermal resistance reveals the interactions that contribute most to stability in different temperature ranges.
Its strengths include the use of separate derivation and validation cohorts, the use of objective measures of internal cluster validity, and the use of two different clustering algorithms.
In African children with severe malaria, high pfHRP2 has been associated with anaemia, coma and death (Hendriksen et al., 2012), and distinguishes presence/absence of cerebral sequestration or malarial retinopathy in separate derivation and validation cohorts (Seydel et al., 2012).
Strain P12's other element was similar to other type 1 elements in gene organization (Fig. S6), but was unrelated to them in DNA sequence for the first ∼8 kb from each end; this divergence indicates derivation from a separate TnPZ lineage.
Combining the ICD10 and Read codes did have a greater effect, but the CIs overlapped with estimates for the separate derivations.
Given the relatively small sample size and the large number of features evaluated, we evaluated for the potential for overfitting by testing the model on a separate, unseen validation dataset separate from the derivation and primary validation datasets.
Scale development involved a derivation sample (n = 6265) and a separate cross-validation sample (n = 1000), both drawn from four universities and Amazon Mechanical Turk.
Because all but one species of Proserpinus are canalized for host plant use, or color pattern, or phenology and physiology, the rapid derivation of divergent unique traits, each in a separate species, strongly suggest that these adaptations are saltational.
