Study with a much larger, separate concordance including a dictionary of Bible and Holy Land atlas of maps, all in one volume, spanning various times in the history of the eastern Mediterranean Sea region, Middle East -- or find a set of Bible commentary books -- all available at bookstores (especially Christian, Jewish and Western-commercial booksellers).
In a post hoc analysis, we assessed the discrimination of age- and sex-adjusted models for each of the 12 end points by calculating the separate concordance index (C-index) for each.
Furthermore, we replicated genotype calls of 200 randomly selected SNPs for a subset of samples using a separate genotyping method with >99.5% concordance.
We also replicated genotype calls for a subset of samples using a separate genotyping method with over 99.5% genotype concordance.
Before the study began, these two investigators independently and together evaluated a separate set of 20 neonates to ensure concordance of observations.
For censored survival data, two main sapproaches have been considered for quantifying the predictive ability of a variable to separate patients: concordance and proportion of explained variation.
All frameworks had high accuracy, and after choosing one we determined that it had >98% concordance with clinical tests in a separate 163-tumor test set.
As a sensitivity analysis, we also tested whether the results remain if treating concordance for missing values as a separate group (Tables not shown).
Our analysis of genotyping quality, using ∼18,000 SNPs contained on the HumanHap300 bead chip, and a separate Human-1 (109,000 sites) bead chip showed a genotyping concordance rate of 99.97%.
Gathering pharmacokinetic data for the parent molecule as well as determining the contribution of metabolites to observed QT interval prolongations, would require a separate effort and was beyond the scope of this particular QT concordance exercise.
