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The peri or post-conceptional period represents a sensitive window during which suboptimal maternal micronutrients may affect feto-placental development [1].
Thus, in mice, gestational day 2-3 may be a sensitive window for BPA and TCS.
Exposure to these two endocrine disruptors during a sensitive window might lead to implantation failure.
The hydrogen/deuterium exchange (HDX) of proteins provides a sensitive window into the molecular interactions and dynamics of proteins in solution.
Our prospective cohort study with longitudinal measurement of maternal PCBs underscores the preconception interval as a sensitive window for human development, and the importance of quantifying a mixture of PCBs by purported biologic activity.
Although a sensitive window for structurally related cochlear impairment would likely originate during prenatal development—in which case the optimal marker would be the PCB concentration in maternal or cord blood deficits in cochlear function that develop postnatally in infancy or beyond may result from alternative mechanisms, mediated by PCB concentrations measured later.
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The determinant variable is the different hormonal milieu to which the brain is exposed during a "critical sensitive window" of perinatal development.
The finding that the results were similar before and after adjusting for postnatal exposure suggests that the prenatal period may be a more sensitive window for BPA exposure [see Supplemental Material, Tables S2, S3 (http://dx.doi.org/10.1289/ehp.1104492)].
We initiated DR on day 2 adults because it had an intermediate effect on lifespan as compared to initiation on day 1, 3, and 4. We reasoned this intermediate effect served as a potentially more sensitive window to detect factors that modify food responses, as the effects of food were non-saturating (unlike the effect of day 3 DR initiation, which was indistinguishable from day 4 DR initiation).
A second limitation of our study is the timing of exposure relative to semen collection, which makes it difficult to identify the sensitive window; this is an issue relevant for all past research as well.
We initially tested 24-hour time windows for sensitivity and then narrowed down the sensitive window.
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