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Collectively, these studies demonstrate that m-aconitase is a sensitive target of ROS generated in cells and tissue.
Aconitase has been well established as a sensitive target of ROS; however the consequences of oxidative inactivation of this important enzyme still remain to be fully understood.
The Müllerian duct also proved to be a sensitive target of toxicity in frogs.
RyR1 is also a sensitive target of THI (Abramson et al. 1995).
We first monitored the expression of a sensitive target of HIF-1, carbonic anhydrase IX (CAIX, Figure 3a).
The endothelium is a sensitive target of PM, and animals and humans exposed to PM show endothelial dysfunction (Brook et al. 2011) and EPC depletion (O'Toole et al. 2010), indicating that PM exposure potentially affects the endothelium by acutely causing direct loss of flow-mediated dilation and, in the long term, attenuating EPC-mediated endothelial repair and regeneration.
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In chronic MeHg exposure, peripheral lymphocytes may represent a sensitive target for the interaction of MeHg with mAChRs and, therefore, may be predictive indicators of later adaptive response involving cerebral mAChRs.
In the hemocyte, the lysosomal function represents a sensitive target for the action of the hormone both in vitro and in vivo.
The immune system is a sensitive target to the toxic action of chemicals in several organisms [19, 30 32].
NifB (cce_0554), a sensitive target for assessing the regulation of N2-fixation [ 15], was also abundant in the dark whereas NifW (cce_0568), a small protein with 116 residues (13.3 kDa) located in the 35 nitrogenase gene clusters, was abundant near the end of the first dark transition, but not observed in the second dark phase.
Alterations in regional brain concentrations of serotonin, dopamine, and norepinephrine have also been described by Bleavins et al. (1984), and a recent study has found that exposure to HCB can produce oxidative stress and that the brain is a sensitive target organ of HCB toxicity (Song et al. 2006).
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