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–Why are fetuses considered to be a "sensitive population"?
Anyone reviewing requests, he said, must consider how compliance with the request might affect the bureau's reputation, whether the request involves a sensitive population and whether the request is for law enforcement purposes.
This work demonstrates the occurrence of engineered nanomaterials in the food supply of a sensitive population (infants) and the need to consider transformations in nanomaterials that occur during use, which result in different exposures between pristine/as-produced ENPs and nanomaterials after passing through the human gut.
A sensitive population with prolonged oxaliplatin-free interval is more likely to benefit from oxaliplatin reintroduction [ 22].
Using the second approach, a NOAEL of 0.005 mg/kg-day (Gibbs et al. 2004) can be identified from thyroid hormone and goiter data in a sensitive population.
Uncertainty factors were not deemed necessary because NOAEL was derived from a chronic study focusing on the critical effect (dental fluorosis) in a sensitive population of humans (children).
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Based on Latendresse et al. (2009) reporting an NOEL for an endocrine-sensitive end point in a potentially sensitive population exposed continuously over multiple generations, application of an additional UF of 10 is protective.
Given that it would be unethical to purposely expose a potentially sensitive population to even trace levels of an environmental toxicant, there is a lack of pharmacokinetic (termed "toxicokinetic" when referring to toxicants) data in elderly individuals.
Although the conditioning period was only 4 h, selection of a more sensitive population in the face of a toxic stimulus would be an unlikely violation of natural selection in the absence of a factor conferring a growth advantage.
"And you've got growing bodies and brains, so if there is going to be an impact, that's likely to be a more sensitive population than others".
"What the study does indicate is that this is a very sensitive population and that any treatment needs to be done with a lot of forethought and constant reevaluation" said Dr. Bruce J. Kinon, a Lilly psychiatrist.
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