CYP1A expression in fishes is inducible by exposure to PCDDs/PCDFs, coplanar PCBs, and some PAHs (Stegeman and Hahn 1994) and is usually a sensitive, dose-responsive, reversible, and specific biomarker to these contaminants and may be predictive of some higher level toxic effects.
Using this sensitive dose of 0.5 ng/ml IL-1, delayed IKKβ phosphorylation was observed compared to treatment with 10 ng/ml (compare Figure 1 and Figure 4B).
Performing dose-response experiments ranging from 10 ng/ml to 0.1 ng/ml IL-1 for 15 min revealed 0.5 ng/ml to be the sensitive dose of choice upon which initial IκBα degradation has only partially taken place.
We designed this study to determine the extent of adrenal insufficiency in cancer patients receiving MA by utilising a sensitive low-dose adrenocorticotropin (ACTH) stimulation test.
Interpretations of results from diet-tissue studies can be improved by acknowledging that the sensitive dose-response range for accumulating n-6 HUFA from linoleic acid is below 0.5%en [ 16].
As a prerequisite, a sensitive IL-1 dose had to be determined allowing observation of minor changes in IκBα levels and IKKβ phosphorylation.
This motivated several groups to look deeper into issue of the dose to a sensitive cell population within the lens, especially for radiations with low energy penetrability that have steep dose gradients inside the lens.
A two-dimensional (2D) dosimetry system has been designed for position-sensitive dose-measurement applications in modern radiation therapy.
To investigate gastrointestinal absorption of intact gluten peptides, we dosed a gluten-sensitive macaque with an isotopically labeled form of the immunotoxic 33-mer gluten peptide [13], and measured its plasma concentration using a sensitive and specific mass spectrometric method.
The discovery of multiple gene dose-dependent phenotypes associated with Df11(1) and Dp11(1) suggested that one or more genes within the region has a critical dose sensitive effect on behavioural, haematological, immune, metabolic, and atherosclerotic phenotypes.
