Exact(1)
A selection of variants that met the above criteria for a somatic mutation (n = 202) were subjected to validation by conventional PCR amplification and bidirectional capillary electrophoresis on the ABI3130 Genetic Analyser using BigDye Terminator v3.1 sequencing chemistry (Applied Biosystems, Foster City, CA).
Similar(59)
Based on a selection of typed variants, it is possible to input a larger number of variants into each individual's genome and thereby have a very high density map of genetic markers [ 137].
This includes a selection of splice variants, non-synonymous SNPs, and N-glycosylated proteins, by selected reaction monitoring (SRM).
The reason to this is not known, but indicates that constitutively active AR-Vs could be part of the normal prostate physiology and that a selection of those variants occurs during PC progression.
SNP selection in the present study considers the full set of SNPs reported in Brandstätter et al. [6] (with the exception of SNP A14552G which is replace here by C3936T; both leading to haplogroup H12) plus a selection of additional variants that define further sub-branches of R0 within Europe; see e.g. [4].
A selection of 25 variants detected by WES was reanalysed by Sanger sequencing.
Thus, the kinetic solubility of a selection of active variants was measured at 37 °C, pH 7.0 (Fig. 5).
Recombinant His-tagged fHbp was prepared from a selection of natural variant fHbps and alanine substitution mutants of fHbp V1, V2, and V3 as described previously (Johnson et al., 2012).
The problem of variable selection is well studied in statistics generally [Miller, 1984] but has perhaps been neglected in statistical genetics, where the aim has been to detect convincing association to a region, rather than pinpoint the causal variant, particularly as most datasets to date have included an incomplete selection of variants in any region.
Despite the mentioned limitations, our study confirms social inequalities in diabetes for different indicators of SES and provides no evidence that a selection of common genetic variants with the largest reported diabetes effects plays a role in the observed health inequalities.
The system will autonomously select an appropriate degree and selection of variants and integrate them within an appropriate fault-tolerant redundancy scheme.
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