These criteria include the presence of a graded monotonic response with dose and a significant dose-related trend in the selected end point(s) (U.S. EPA 2000).
Because the selected end point is related to a physical property of a membrane protein, the NIS, the interindividual variability is likely to be less than that of changes in serum thyroid hormone or TSH level.
Of the 283 chemicals with a rat chronic/cancer study, 218 were positive in at least one of the selected end points, whereas 155 of 276 chemicals with a mouse cancer study were positive in at least one selected end point.
Note that Fig. 3 shows data for iterations 1 50 to highlight the rapid TARC increases between 1 and 10 iterations, but above 10 iterations, the TARCs remain stable up to at least 100 iterations, which was the selected end point.
In the present study we demonstrated that BPA, BPA-DM, nNP, and nOP elicited an impact on most of the selected end points: ER, AR, AhR, and aromatase activity.
If non-inferiority was confirmed, the trial also aimed to show superiority of IDegAsp on selected end points based on a hierarchical testing procedure.
These discordant findings may be related to a variety of factors, including dose, exposure route, internal dose, timing, and selected end points.
We present Kaplan-Meier curves for each treatment group for selected end points and procedures.
Unsupervised hierarchical clustering of the 16 rat end points and the 9 mouse end points displayed the relative distribution of the selected end points and chemicals.
Table 4 combines key pharmacokinetic results from the two Papua New Guinea studies, comparing selected end points for chloroquine [ 112] and azithromycin [ 97].
