Our screen led to the identification of at least six novel compounds that exhibited validated selectivity in a secondary dose-response assay [see Additional file 8, Figure S4].
This differential response to ponatinib as compared with dasatinib was confirmed in a secondary dose-response study, which showed comparable drug sensitive profile for samples of the patient obtained at diagnosis and at R1. Exon sequencing did not show any ABL1 mutation that could account for the differential response to the two drugs.
Importantly, wild type mice developed immunity through the priming dose that protected them against a higher secondary dose.
The unfiltered beer moves in from a secondary fermenter, is dosed with DE in a chamber that doubles as a sight glass, moves through the filter elements in the large tank, comes out of the large tank filtered, moves past a sight glass, and is then directed into a bright tank.
This result was probably explained by the fact that the patient with a dose reduction up front has a secondary increase of chemotherapy dose if the tolerance was good (nine patients).
Y-90 activities were determined from a stock solution measured under calibration conditions with a Fidelis secondary standard dose calibrator.
After this primary treatment, all patients got a secondary treatment with high dose vitamin D. The first years we started with a treatment with vaginal tampons with 5000 IU vitamin D and olive oil (vitamin D on the long side of the tampon, every night, for six weeks).
We therefore conducted a secondary analysis alongside a dose-response, randomized controlled trial of spinal manipulation.
The paper called the tumors "a secondary biological response to dose-dependent hepatotoxicity" and pointed out that male B6C3F1 mice are predisposed to develop spontaneous liver tumors.
Each r-GV elicits a solid peptide specific antibody response to the initial low dose, demonstrates a secondary response to the booster and a natural waning of antibody titer over time, as shown by assay of the 12 week post booster sera.
The biodistribution of [18F]FDG-6-P washownwn to be visually comparable with that of [18F]FDG, which had been similarly administered by ip injection into a secondary cohort of mice (administered doses ranged between 8 and 11 MBq).
