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The phrase "a second question is that" is correct and usable in written English.
It can be used when introducing an additional question in a discussion or written piece.
Example: "A second question is that, how do we ensure the project's success?"
Alternatives: "Another question is" or "A follow-up question is".
Exact(1)
A second question is that although it is clear that oncogenic miRNAs may act as tumor suppressors and vice versa, when, where, and how do such interchanges of role occur.
Similar(56)
A second question is how far that trend will go.
One possibility, consistent with the majority interpretation that Locke provides a negative answer to the second question, is that Locke is providing an argument here for the claim that the proposition that it is possible to be free with respect to willing to do an action leads to a vicious infinite regress of wills.
A second question is this: since the reflection that is involved in autonomy (and which, according to this view, is the source of normativity) need only be hypothetical reflection upon one's desires and mental capacities, then the question arises: under what conditions is this hypothetical reflection meant to take place?
Lewis's answer to the second question is that a pre-existing convention is so overwhelmingly salient that agents expect one another to abide by it, an expectation which furnishes reason to conform.
The answer to the second question is that, when a car accelerates unexpectedly, the driver often panics, and just presses the brake harder and harder.
My reply to the second question is that, after a short time, I don't think about anything – other than trying to accurately cast a fly to a rising fish.
The second question is that of a metatheory.
The answer to the second question is that people are nuts.
In addition, in order not to underestimate the awareness of the population, a second question was added 'Do you think that modern medicines can be harmful in case of normal use and normal doses?'.
As Barkley began to ask a third question, Popovich interrupted, "That's a third question, isn't it?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com