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Although acute lymphocytic leukemia (ALL) is commonly considered to be a childhood disease, ALL has a second incidence peak at around age 50 years and steadily increases in incidence with age.
There is a second incidence peak between the age of 8 to 14 with a male predominance.
The age of diagnosis in Asia is slightly higher than that in European countries and there is rarely a second incidence peak.
The corresponding values for a first incidence screen were 1.7%and90%0% and for a second incidence screen were 1.1%and94.5%5%.
Seventy percent of patients are aged 25 45 years, although a second incidence peak occurs in women older than 50 years in Europe and Japan [ 4, 5].
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To add further complexity, it is possible for people to miss incidence screens but to respond to subsequent invitations for example, someone who undergoes prevalence screening at the first invitation (in the first screening round) may decline a first incidence screen in the second round but accept it when it is offered again in the third round.
The uptake of first incidence screening on a first invitation was 54% and on a second invitation was 86% and on a first invitation for second incidence screening was 46%.
In addition to this peak incidence at middle age, a second peak incidence is described in the literature for a younger age group, 10 to 29 years.
Of these invitations, 307 235 were first incidence screens on a first invitation, 123 142 were first incidence screens on a second invitation, and 214 985 were second incidence screens on a first invitation.
Interestingly, in addition to the incidence peak in the summer months, we observed a second, smaller incidence peak of campylobacteriosis in January.
The uptake of the first incidence screening on a first invitation was 54%, first incidence screening on the second invited was 86%, and second incidence screening on a first invitation was 46% (fig 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com