A genetic screen was developed to identify suppressor mutations that restored catalytic activity in vivo from two kinase-dead Protein Kinase A mutants in S. cerevisiae.
A genetic screen was developed to identify suppressor mutations that could restore catalytic activity from a kinase-dead mutant of PKA.
A mutagenesis screen was developed with the goal of testing whether single gene mutations could mimic the dosage effects that are found in segmental aneuploids.
Finally, an operator screen was developed and connected to the dynamic simulator via UniSim Excel Interface Tool.
In a search for chemical compounds that could restore normal cholesterol distribution in NPC mutant cells, an automated microscopy screen was developed to identify compounds that partially correct cholesterol accumulation in Chinese hamster ovary (CHO) NPC1-deficient cultured cells [39].
To test the behavior of aromatic oligoamides in cells, a high-content imaging screen was developed.
Interestingly, a novel computational-based screen was developed to identify lead compounds targeting the ubiquitin-mediated proteasomal degradation of frataxin (Rufini et al., 2011).
A robust and reliable color screen was developed for protein engineering to improve its activity on hydroxylated carotenoids for astaxanthin production.
A three-item palliative care screen was developed from consensus reports.
