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Those that reward the stringent demands and tests of such endurance as sitting for 24 hours straight gazing at a screen of human flux and mayhem with the prize of epiphany?
Another point mutation first identified in a megakaryoblastic cell line derived from an acute megakaryoblastic leukemia (AMKL) patient, and subsequently detected in a screen of human AMKL cell lines for STAT5 activation, presented a T875N substitution in the kinase domain of JAK2 [29].
In a screen of human melanoma tumor samples, copy number greater than 1,000 for IL-1β was present in 14 of 16 biopsies, whereas none expressed IL-1α. [ 29] Similar findings were observed for colon carcinoma and non-small cell lung carcinoma.
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This last feature is expressed as either "positive" or "negative" depending on the results from a screening of human MHC ligands derived from the database MHCPEP [ 21].
The PTEN gene was originally identified by three independent groups using different methodologies: a representational difference analysis of tumours; a high-density scan of chromosome 10q in glioma cell lines and a screening of human cDNA libraries designed to detect protein phosphatases upregulated in response to transforming growth factor β (TGF- β) (Maehama et al, 2001).
A screen of the human genome database with the Fugu proteins yielded 10 h/E spl)/hey-related genes.
A screen of a human aorta cDNA library revealed SESTD1 as a binding partner of TRPC4 and TRPC5 (Miehe et al. 2010).
During a screen of the human genome for retroviral open reading frames [ 25], we identified a new group, dubbed HERV-V [ 18], containing two almost identical envelope genes.
Cut to a split screen of human and robots kissing passionately.
A recent screen of human cartilage has shown that multiple members of the ADAMTS family may be important in connective tissue homeostasis and pathology.
Melanomas with V600E BRAF mutations frequently accumulate nuclear β-catenin and, interestingly, GSK3A and GSK3B were recently shown to be negatively regulated by V600EBraf/Mek/Erk signalling in a phosphoproteomic screen of human melanoma cells following MEK inhibition (Old et al, 2009).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com