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Such a deviation was simply a biased (transformed) feature rather than a scattered type.
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This "scattered type" staining of p53 may rather reflect an accumulation of wild-type p53 protein as a result of either a response to DNA damage, alterations in the normal degradation process, or the stabilization of the gene product by an interaction with viral or cellular proteins 34, 35.
"Scattered type" may reflect normal p53.
Two "aberrant type" and two "scattered type" were analyzed.
It seemed that "scattered type" reflects wild-type p53.
In "scattered type," chromosome 17 did not have aberrant structure.
The staining pattern does not match with "scattered type".
There was no relation with clinicopathological factors between scattered type and aberrant type (data not shown).
This result may reflect our results; "scattered type" tumor has wild-type TP53 gene.
Also, we found that the entire "scattered type" staining group had wild-type TP53 gene.
In our study, we focused on "scattered type" and wild-type TP53.
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