Comparison of gene selection approaches: Because there is overlap between the gene types for some pairs of conditions, there must exist a sample consistent with some condition that cannot be classified correctly as that condition.
Similarly, we found a 1-year survival rate for such patients of 11.3% in our previous AHCC01 trial, which recruited a sample consistent with the present trial regarding ethnic composition, treatment-naivete and proportion of patients of poor functional status (Child-Pugh B, C or ECOG 3).
5 7 8 The analysis is based on a small sample (consistent with qualitative methods) and relied on reported practice rather than direct observation, but is strengthened by inclusion of multiple professional perspectives.
Another striking difference between MNA and CRC is the absence of TP53 mutations, except for a high-grade sample, consistent with the association of high-grade histology with increased chromosomal instability.
Interestingly, a borderline significant association (P = 0.058) was observed between age and saliva volume, suggesting that older subjects may have been more likely to provide a 0.5 mL sample, consistent with reports that xerostomia (dry mouth) prevalence increases with age [ 8].
However, these two bands were reduced to a single 137-kDa non-glycosylated SUR2 in the PNGase F-treated sample, consistent with a prior report on the SUR1 de-glycosylation study [ 29].
For these reasons we cannot be certain of the size of the genetic effect until the entire gene has been extensively investigated by re-sequencing and identification of all potential functional variants; either there is a small effect across the entire sample (consistent with multiple additive genetic effects) or a large effect in a subset of samples (consistent with genetic heterogeneity).
This sample of maize inbreds has 57 % of SNP variability found in the teosinte sample, consistent with a population bottleneck during domestication and maize improvement.
The fewest unique transcripts were present in the 8 dpp sample, consistent with a developmental gradient of transcription moving from 0 4 to 8 to 12 16 dpp.
We did not observe a significant association between the SNP and the risk of PTSD in our Chinese Han sample, consistent with a previous study [ 46], in which no relationship between rs10482605 and cortisol responses to psychosocial stress was found in a child psychiatric population.
Analysis was also stratified based on BMI categories (i.e. desirable, overweight, obese), and also by using the median BMI of the sample, consistent with an earlier study [ 15].
