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We know that the mechanism of most MDMA-related deaths is similar to overheating (which is exacerbated by hot club or festival environments), and that a small dose is a safer dose.
One was a safer dose (1/10th of LD50 = 500 mg/kg), second was higher than the safer dose (1000 mg/kg) and third was lower than the safer dose (250 mg/kg).
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Therefore, a safer dosing scheme for danaparoid was tested, based on a mathematical model aiming to achieve a peak anti-Xa level of less than 1.0 and a maintenance level of between 0.5 and 0.7 anti-Xa U/ml.
Therefore, we decided to design a safer dosing scheme for danaparoid, based on a mathematical model aiming at a peak anti-Xa level of less than 1.0 and a maintenance level of between 0.5 and 0.7 anti-Xa-U/mL.
What, then, can be a "safe dose" of DDT?
"I do not believe that one can establish a safe dose of carcinogens," he said.
A safe dose, determined from testing in animals, is used as the starting dose.
More recently, Merck began its study to find a safe dose.
One memorable project involved trying to work out a safe dose for methadone, a substitute drug given to withdrawing heroin addicts.
"I do not think that we have the method or evidence available by which we can reliably determine a safe dose".
However, doctors know that there is no such thing as a safe dose of radiation, and that radiation is cumulative.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com