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The first step consists in the derivation of a statistical model and mutagenicity prediction, followed by further checks for specific structural alerts in the "safe" subset of the prediction outcome space.
We assessed the impact of quality of genomes on our conclusions, by restricting our analyses of the taxonomical and functional distribution of composite genes to a very stringently defined "safest" subset of 6,144 composite genes, using three additional conditions.
Dendritic cell vaccination is a safe strategy that has shown some efficacy in a subset of myeloma patients and may become a crucial part of MM treatment when combined with immunomodulatory drugs or immune check-point blockade.
For that subset, it's a lot more effective to offer them a safe and secure place to use those drugs".
A safe bet, perhaps.
Have a safe weekend.
"Have a safe New Year".
A safe city.
A safe implementation requires.
From a safe distance. .
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