Sentence examples for a safe phase from inspiring English sources

The primary aim of this study was to evaluate the ability of rodent-only toxicology studies to identify a safe phase I trial starting dose.

A recent review of the data on the first 25 compounds to be studied (Newell et al, 1999) confirmed that rodent-only toxicology provides a safe Phase I trial starting dose and predicts toxicity for the vast majority of the agents investigated.

The aim of the study was to determine the maximum tolerated dose (MTD), the dose limiting toxicity (DLT), and the pharmacokinetic profile (Pk) of bendamustine (BM) on a day 1 and 2 every 3 weeks schedule and to recommend a safe phase II dose for further testing.

However, it is important to stress that in no case was toxicity unacceptable at the Phase I trial starting dose and the experience of the Committee, with a wide range of agents, is that rodent-only toxicology does provide a safe Phase I trial starting dose (Newell et al, 1999).

Thus demolition of buildings is now a well-planned part of civil engineering, with many aspects to ensure a safe demolition phase.

Given that the THA is safe, phase B studies must be conducted to evaluate the clinical performance of the THA regarding pain relief and functioning (clinical scores and patient-reported outcome measures (PROMS)) and to determine the rate of complications within a limited period that is feasible (e.g. severe adverse effects of the implant).

Once the THP is considered safe, phase B studies must be conducted to evaluate the clinical performance of the THP regarding pain relief and functioning (clinical scores and patient-reported outcome measures (PROMS)) and to determine the rate of other complications (e.g. pseudotumors) (Pandit et al. 2008).

If the TKP is considered safe, phase B studies should be conducted to evaluate the clinical performance of the TKP regarding pain relief and functioning (clinical scores and patient-reported outcome measures (PROMS)) and to determine the rate of expected or unexpected complications.

Subsequent cohorts of patients were treated at intermediate dose levels of 170 and 200 mg m−2 in order to define a safe dose for phase 2 studies.

In this trial, 21 patients were enrolled and treated with doses ranging from 15 to 100 mg/m, with 100 mg/m being considered a safe dose for phase II studies.

Mr. Warner said that if President Clinton could not certify that the Europeans had met their commitments in Kosovo, he would call for the remaining $1 billion to be used for a "safe, orderly and phased withdrawal" of American soldiers.