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The suggested design provides a safe penetration depth, reduced moment and anchor force based on reliability theory.
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Automated devices which allow for a standard safe penetration of the vascular bed have been recommended for the heel prick procedure [ 10].
To discern the composition of penetratin for safe penetration from cornea to retina, we designed a series of penetratin derivatives by varying the hydrophobicity and evaluated their potency for retina-targeted delivery.
These are (1) the ability to cut with a broad range of fluences without impacting the location of the focal plane, which is desirable given tissue differences (2) the use of beams which have longer working distances facilitating delivery, and (3) precise axial ablation with these beams enabling safer penetration up to sensitive boundaries or membranes.
In terms of ADMET analysis, Budmunchiamine L5 has good absorption, BBB penetration, and less toxicity in the human liver and may therefore be regarded as a safe lead drug for designing a novel ApoE4 inhibitor for AD therapy.
A safe bet, perhaps.
Have a safe weekend.
"Have a safe New Year".
A safe city.
A safe implementation requires.
From a safe distance. .
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