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It is desirable to use a safe agent with fewer adverse effects for this purpose.
Both cell toxicity and ROS generation assays indicated that the purine derivative 3c showed low cytotoxicity and could be used as a safe agent.
Dexmedetomidine is a safe agent for ICU sedation.
Fluconazole is a safe agent that can be administered orally, intravenously, subconjunctivally or topically.
DDAVP appears as a safe agent to develop strategies for a pharmacological modulation of angiostatin production and tumor-endothelial interactions [ 15].
Being the main ingredient of curries and thus part of the everyday diet of millions of people, Curcumin is considered a safe agent in humans [ 5, 6].
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For instance, instead of injecting a contrast medium directly into the fluids of the nervous system, we now inject into a vein a safer agent (which then percolates round the body) and perform an MR scan – much easier, safer and less painful then the former method.
Curcumin is a pharmacologically safe agent with many activities including a powerful antioxidant function and anti-inflammatory properties.
Interestingly, even though BMS is cytotoxic to some tumor cells and can sensitize MCF-7 human breast cancer cells to IR, it is a relatively safe agent that does not cause noticeable normal tissue damage in vivo [19] [21].
Gefitinib has been generally considered to be a relatively safe agent.
Ether, on the other hand, is a relatively safe agent with its main side effect being postoperative nausea and vomiting.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com