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Telomeres are thought to have several vital functions in addition to protection of the chromosome ends, such as providing a mechanism for distinguishing between real chromosome ends and breaks that need repairing, having a role in alignment and segregation of chromosomes during meiosis, modifying gene expression, and contributing to stress resistance in cells and tissue [1] [3].
In this regard, consensus sequences of up to 19 nucleotides flanking attM have been identified in the genomes of S. lividans [ 14] and M. smegmatis [ 16], suggesting a role in alignment of the integration site.
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It is implied that the nine residues linking the two domains play a role in this alignment, but this has not been established.
Aurora A has a crucial role in mitotic bipolar spindle formation and localizes to centrosomes at the proximal mitotic spindle, whereas Aurora B localizes to kinetochores, phosphorylates histone H3 at Ser10, and has a role in chromosome alignment and cytokinesis.
In addition, D623 is located at the tip of a β-hairpin, which has been shown to play a role in the alignment of the primer terminus with an incoming dNTP.
We believe that the addition of Fe layer plays a crucial role in alignment of CNTs due to the formation of uniform layer of Fe catalyst nano particles on the surface of the substrate [14].
The purpose of the present study was to extend this approach by evaluating whether the presence of stereopsis developing immediately after surgical alignment or optical correction plays a role in maintenance of long-term alignment.
Implant alignment plays a role in both survival and functional outcome following primary TKA, as component malalignment can lead to increased failure rates, maltracking, and knee pain.
The spliceosome presumably plays a role in folding the pre-mRNA for proper alignment of the two splice sites so that the splicing reaction can take place.
Malalignment mediated 37 to 53% of the association between bone marrow lesions and progression of OA of the knee, suggesting that knee alignment may have a role in the occurrence of bone marrow lesions.
Another approach is to try to retrospectively analyze which alignment efforts have played a role in realizing contributions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com