Less robust susceptibility effects have been reported for non-MHC related genetic variants.
Thus, the 9p21 SNP is now considered as one of the most robust susceptibility variants of myocardial infarction and/or CAD in the primary prevention setting.
To date, T2D GWAS efforts including samples of European [ 34, 35, 36, 37, 38], East Asian [ 39– 45], South Asian [ 46, 47], Mexican/Mexican American [ 48] and African American [ 49] descent have delivered 76 robust susceptibility loci [ 50].
Less-robust susceptibility effects have been identified for MHC class I alleles and for non-MHC regions.
More recently, the same authors expanded their analysis to a total of 608 LCLs and >3 million SNPs, reporting a robust association between CDDP susceptibility and a SNP upstream of keratin 16 pseudogene 2 (KRT16P2) as well as a link between the sensitivity of LCLs to CDDP and SNPs affecting BCL2, ERCC2, ERCC6, glutathione S-transferase μ1 (GSTM1) and glutathione S-transferase θ1 (GSTT1).
However, for none of the other susceptibility genes, a robust association with any of these clinical subphenotypes could be shown.
By combining competition between fluorescently labeled bacterial strains with a robust test of bacterial drug susceptibility, we have produced a simple and flexible assay which allows visualization of both the absolute inhibitory effect of compounds as well as the differential selection that they impose on strains sensitive and resistant to a chosen antibiotic.
Therefore, TNFAIP3 seems a robust candidate gene for RA susceptibility.
Our results suggest that a rapid and robust antimicrobial susceptibility test (AST) can be constructed by statistically characterizing the differences between sample and control flow cytometric populations, even in a label-free scheme with scattered light alone.
This may explain the higher susceptibility of preterm infants to respiratory infections, as a robust autophagy response is essential for clearance of common lung pathogens like Pseudomonas aeruginosa (Pa).
