Thus, while blockade of system xc− by erastin (and other agents, see below) can trigger a robust transcriptional signature indicative of ER stress, it is doubtful that this transcriptional response is essential for the lethality observed following erastin treatment.
For the High-Pb group, treatment with succimer provided a robust benefit on measures indicative of impaired regulation of arousal or affect one of the most pervasive areas of impairment seen in this group, and a major cause of their impaired performance overall.
Although there were no gross phenotypic abnormalities at birth, subtle epidermal anomalies were present that disappeared by one month of age, indicative of a robust injury response.
Z′ factors greater than 0.50 are indicative of a robust assay.
These data demonstrate that revC3 expression induced a 'non-leaky' cell death, indicative of a robust model system.
A marked cleavage of PARP, indicative of a robust apoptotic response, became evident only upon 144 h of serum withdrawal (Fig. 2A).
In these experiments, calculation of the Z′ statistic for TP1, using reference antagonists (Table 5 ) gave values exceeding 0.5 in each case, indicative of a robust assay.
The phantom results are indicative of a robust quantitative method for analysis of Tl SPECT data that should extend to clinical imaging.
This observation led us to conclude that the poor overlap was probably not a technical issue, but could rather be indicative of a robust difference between the genotypes that had a biological basis.
Moreover, GEP data showed that injected GBM cells underwent a dramatic decrease in c-JUN, VEGF, LDHA, GAPDH, and ALDOA, indicative of a robust decrease in proliferation, angiogenesis, and glycolysis related genes.
