Exact(5)
These results are in line with the finding that the GRN in question is a robust developmental module that is widely conserved among flowering plant species [3].
Situs solitus is seen in almost everyone, so it is clear that the determination of situs is controlled by a robust developmental mechanism.
Thus, high (low) concentrations of food or low (high) temperature can efficiently inhibit (promote) pheromone-induced dauer formation, allowing animals to assess and integrate diverse sensory cues in order to make a robust developmental choice.
In their extensive meta-analyses of 50 published studies (N = 29,839) and four large national studies (N = 74,381), Trzesniewki et al. found evidence for a robust developmental trend.
Previous studies with Plp1-lacZ transgenic mice (Wight et al., 1993; Li et al., 2002b) have shown that inclusion of Plp1 intron 1 DNA in the transgene is crucial to attain a robust developmental increase in β-gal activity in brain, concurrent with the active myelination period of CNS development.
Similar(55)
In their study, the Abbott lab members identified six miRNAs involved in gonad morphogenesis (Brenner et al. 2010), a normally robust developmental process that is dependent on the migration of two distal tip cells (DTCs) (reviewed in Wong and Schwarzbauer 2012).
Following this idea, it is interesting to note that recent studies that aimed to explain the underlying mechanistic basis of robust developmental networks suggest that, robustness is highly dependent on the dynamic nature (either transient or stationary) of expression patterns [51] [53].
An understanding of the molecular details of these processes, in normal development and in disease, requires robust developmental models for the human system.
Caution should, however, be taken to draw anatomic conclusions from such studies without considering robust developmental and anatomic studies.
Dynamical models are instrumental for exploring the way information required to generate robust developmental patterns arises from complex interactions among genetic and non-genetic factors.
As with the whole lung, the population of macrophages purified from the BAL exhibited robust developmental patterns, evident at all time points (Tables 6, 7 and 8).
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