Sentence examples for a robust activation of from inspiring English sources

However, incubation of lysates at 37°C induced a robust activation of caspase-1 activity that was inhibited by 130 mM/K+ as reported previously 20.

Both isoproterenol and PMA were found to provoke a robust activation of RACK1-associated PDE activity, which was completely ablated by co-incubation with GFX, indicating that the stimulation of PDE activity by both agents requires PKC.

Serum-starvation was performed to downregulate PKA activity so that a robust activation of PKA could be detected upon stimulation of intracellular cAMP levels in the presence or absence of the STAD peptides.

Mechanistically, Slit2 induces a robust activation of PKA signaling, which is required for its prothermogenic activity.

Ligand stimulation in both cases gave rise to a robust activation of HIF2α mRNA expression, which was abrogated by the γ-secretase inhibitor 5-difluorophenylacetyl-L-alanyl-2-phenylglycine-1,1-di-methylethyl 5-difluorophenylacetyl-L-alanyl-2-phenylglycine-1,1-di-methylethyl 5-difluorophenylacetyl-L-alanyl-2-phenylglycine-1,1-di-methylethyl 5-difluorophenylacetyl-L-alanyl-2-phenylglycine-1,1-di-methylethyl 5-difluorophenylacetyl-L-alanyl-2-phenylglycine-1,1-di-methylethyl 5-difluorophenylacetyl-L-alanyl-2-phenylglycine-1,1-di-methylethyl 5-difluorophenylacetyl-L-alanyl-2-phenylglycine-1,1-di-methylethyl 5-difluorophenylacetyl-L-alanyl-2-phenylglycine-1,1-di-methylethyl 5-difluorophenylacetyl-L-alanyl-2-phenylglycine-1,1-di-methylethyl

Overexpression of CIITA caused a robust activation of the endogenous HLA-DPB1, HLA-DMA and HLA-DOA genes, but this stimulatory effect was not further augmented upon CNOT2 depletion (Fig. 7A).

It is known that acute influenza A virus infection is capable of inducing a robust activation and expansion of suppressive Treg response, which are critical for suppressing excessive immunopathological responses to pathogens through the secretion of large amounts of IL-10.

The differences between these cells may be the result of a more robust activation of diverse signaling pathways activated by CXCR4 and the use of insensitive Gα chain used by CXCR4.

Array expression analyses showed a robust activation in MDAMB231 cells of the known ISR markers, such as CHOP, TRIB3, HEPRUD, ASNS, and solute carriers, while upregulation of some of these was weak or absent in BT474 and MCF10A (Table 2).

While an increase in cellular GSH levels inhibited chemotherapy-induced apoptosis, it resulted in a more robust activation of JNK, Bim induction, Mcl-1 degradation, and associated thiazolide-induced cell death.

We hypothesize that the superiority in this specific therapeutic effect of EPO- α with respect to EPO-Z might be related to a more robust activation of the cell cycle machinery.