We built a rigorous, sequenced, graph-based strategy of network phenotyping analysis (NPA) to combine data smoothing to minimize stochasticity, multivariate analysis to identify ambiguity and prioritize key variables, and k-partite graphs to visualize coherence.
By rigorous sequence analysis of nDNA-encoded subunits of complex I in primates, we identified three subunits (NDUFA1, NDUFA4, and NDUFC2) that exhibited accelerated amino acid rate of change, suggesting their candidacy as coevolving with the fast evolving mtDNA-encoded subunits (Mishmar et al. 2006).
Using our updated catalog of motifs, we predicted TFBSs in S. cerevisiae using MotEvo, a Bayesian TFBS prediction algorithm that combines matches to a given PWM with a rigorous analysis of orthologous sequence segments across related species using an explicit statistical model of TFBS evolution (van Nimwegen 2007).
To date, the only detailed characterization of SIDER sequences is a rigorous manual alignment of 1013 L. major (Lm) SIDER2s set forth by Bringaud et al. [ 21], while the SIDER1 subgroup has yet to be properly portrayed.
The methodology, which includes a sequence of rigorous analyses and calculations, is intended to reduce the addition of uncertainty to the climate data as a result of the downscaling while providing the fine-scale climate information necessary for ecological analyses.
We also conducted phylogenetic analyses of ATV in comparison to other Ranavirus genomic sequences to provide a rigorous test of monophyly vs. a pattern of nonmonophyly resulting from repeated host-switches, as well as timing of the emergence of ATV to assess human involvement in its geographic spread.
This unique data resource allows for a rigorous assessment of the requirements for finishing sequence of diverse origins; the current study reveals substantial differences in the effort needed to finish the sequence from different genomic regions and, in particular, from different species.
We performed a rigorous search for enriched sequence motifs in the largest dataset of OR promoter regions analyzed to date.
This is the first semester of a rigorous two-semester sequence in advanced microeconomic analysis for MPA/ID students.
A rigorous measure of the degree of order in any symbolic sequence is given by the entropy [15].
Computational protein design, or CPD, represents a rigorous test of our understanding of the biophysical mechanisms that shape protein sequences and structures [35] [39], [43] [65].
