Perhaps this approach can be extended to make the model parameters explicit functions of climate and soil, leading to a rigorous, individual-based understanding of observed regional variation in forest structure and species composition.
Cage cards may be all that is necessary for many studies but rigorous individual identification is often required for drug safety studies done according to Good Laboratory Practice (GLP) regulations and for other types of experiments.
Panviral microarrays are useful for broad surveillance of bloodborne pathogens (9 ), yet rigorous individual probe validation across multiple targets is needed because of potential cross-hybridization artifacts.
If the focus is on a rigorous test of individual hypotheses (e.g., in the discovery of individual biomarkers), conservative family-wise error correction methods are warranted, such as the Bonferroni correction.
However, a rigorous assessment of the individual benefits of these costimulatory components relative to the in vivo performance of infused T cells in patients is still lacking.
While there are many ways to evaluate the breadth of a T cell response [56], [57], [58], we chose to take a rigorous approach by mapping individual epitopes targeted by the vaccine-induced response, and evaluating the ability of the epitope-specific T cells to recognize circulating clade variants.
The DCE (alternatively known as conjoint analysis), on the other hand, is a rigorous method of eliciting individuals' preferences in that 'it allows estimation of the relative importance of different aspects of care, the trade-offs between these aspects, and the total satisfaction or utility that respondents derive from healthcare services'[ 11].
Rather, it reflects a keen intelligence and a rigorous, disciplined understanding of each individual element of modern game design and production.
Thus, after her systemic and individual treatments, a rigorous clinical monitoring of disease relapse and metastasis is necessary.
4 An important component of the management of these individuals is a rigorous attempt at characterizing their arrhythmic substrate both for targeted management of arrhythmia risk and to direct genetic testing.
Epidemiologic studies for clinical and population-based research are obligated to define the disease in a rigorous, reproducible way to differentiate individuals with asthma from those without asthma, usually without the luxury of repeated observations.
