An initial round of coordinate refinement was performed using each of the ribosomal subunits as a single rigid group.
A novel rosin-based ester tertiary amine (RETA) with three hydrophilic groups and a rigid hydrophobic group was synthesized from rosin by Diels-Alder addition, acylation and esterification reactions.
Part of the problem, he said, was that policymakers, journalists and online commentators were themselves urban hukou-holders and as such formed a "rigid interest group", posing a "severe" challenge to reforms.At the same time many holders of rural hukou, despite the discrimination they suffer, are suspicious of moves to give them urban status.
A molecule of alumina was represented as a rigid unified group of five atoms and occupied five neighbouring lattice sites.
Compounds having a rigid linker group such as vinyl, ethynyl and phenyl showed significant inhibitory activity against a variety of cancer cell lines.
Integrated evaluation of NMUR1 and NMUR2 binding affinities in vitro and anorectic activity in mice revealed that the introduction of a linker with a rigid ring group, e.g., 2- piperazin-1-yl)acetic acid (PipAc), yielded a highly potent anorectic peptide, PEG30k-PipAc-NMU-8 (14), possessing improved receptor binding affinity.
Alternative prodrugs such as FTI-277 were synthesized in which the central portion of the CAAX mimetic was replaced by a rigid spacer group [ 11].
In addition, all of the Uaas developed to target Cys are derivatives of phenylalanine, containing a rigid aromatic group in the side chain, which prefers a hydrophobic microenvironment and may limit flexibility in bond formation.
At the latest follow-up, dorsiflexion remained significantly lower (p = 0.03) in the rigid group (6°, range: −5° to 12°) than in the mobile group (8°, range: 0° to 15°).
But a rigid subspecialty grouping is rarely done in the main body of an academic faculty.
