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Several studies have suggested that a potential mechanism for estrogen-mediated neuroprotection following experimental stroke is a result of modulating glutamate-mediated excitotoxicity.
Vitamin D reduces local and systemic inflammatory responses as a result of modulating cytokine responses and reducing Toll-like receptor activation.
This indicates that PSLs influence immune cell trafficking towards the CNS, in addition to or as a result of modulating the macrophages phenotype or T cell proliferation.
Although the +TIP behavior of TACC3 is clear, we could detect no change in microtubule dynamics as a result of modulating TACC3 levels in cells.
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The first-generation inhibitors are moderately potent and nonselective and therefore the results obtained from their application may not be a direct result of modulating SphK1 activity but rather a consequence of off-target effects.
However, it remains possible that the activations seen in these studies result from actively inhibiting eye movements rather than as a direct result of modulating perceptual processing.
This may be a result of the drug modulating the Na+ channels immune cells, thereby exerting its neuroprotective effects via immunomodulation and not directly upon CNS axons as hypothesized.
Indeed, several spectacular failures have occurred as a result of attempts to modulate the inflammatory response in sepsis, occasionally even resulting in increased mortality [ 6].
Our findings suggest that type-selective muscular degeneration and endomysial fatty growth as a result of atrophy may modulate the infiltrating growth characteristic of intramuscular lipoma.
Thus, variation of methylation in the non-CpG regions as a result of HMFA may modulate epigenetic-mediated transcriptional repression, although a direct causal connection cannot be established with our data.
ATP stimulation promotes exocytosis in astrocytes (Pangrsic et al., 2006) and ATP released from astrocytes as a result of neuronal activity modulates synaptic transmission (Zhang et al., 2003).
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CEO of Professional Science Editing for Scientists @ prosciediting.com