Importantly, epigenetic modifications of both DNA and histones are time- and tissue- or organ-specific; as a result, disruptions of the epigenome can have vastly diverse consequences, depending on the developmental stage and tissue or organ affected.
Operation Stack has been in effect for 13 days out of the past 20 as a result of disruption at Calais caused by the migrant crisis, industrial action by ferry workers and protests by French farmers.
In mdx heart, the communication between the L-type Ca2+ channel and the mitochondria is altered as a result of disruption of the cytoskeletal architecture.
Leukaemia arises as a result of disruption to haematopoietic precursors, caused either by acquired gene fusions, gene mutations or inappropriate expression of the relevant oncogenes.
Collectively, either lse2 or lse3 would be a result of disruption of a single gene distinct from LSE1 (located on chromosome 6), although neither LSE2 nor LSE3 has been identified.
Patel et al. (2006) have suggested that lead-induced ionoregulatory toxicity in rainbow trout, particularly the disturbance of Ca2+ homeostasis, is not exclusively a branchial phenomenon, but is in part a result of disruption of ionoregulatory mechanisms at the kidney.
Thus, the second step repeated the simulation in a model which lacked H30, to confirm that the observed microdomain is not a result of disruption of normal cellular signaling or unbalanced FRET sensor expression.
The hypothesised selective disadvantage of transposable elements may in many cases be a result of disruption of the informational content of the sequence in which the transposable element is inserted.
Dysphagia typically refers to difficulty in eating as a result of disruption in the swallowing process.
