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Corticosteroids have potent anti-inflammatory activity but potential benefits or adverse effects of corticosteroids in a restricted dose and frequency of administration for traumatic joint injury have not been resolved and remain to be studied.
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There appears to be a lack of awareness of this low vs. high-dose phenomenon in the toxicological risk assessment community, as many toxicological studies, in which effects only occur in a restricted "low dose" range while the effect is not seen at higher doses, conclude that there is no relationship between dose and response rather than that the relationship is nonmonotonic.
However, the dose-response effect over the restricted dose range of 0 to 0.5 Gy was not significant.
The excess relative risks per Gy for heart disease over restricted dose ranges were similar to that for the full dose range.
For the lung, the linear model detects some significant activity in restricted dose ranges, but the results are very different, and combining the two dose ranges yields insignificant results.
Intraoperative radiotherapy is one option to deliver high doses to a restricted area at risk i.e. the adjacent tissue to the tumour cavity after tumour resection.
Dose monitoring and benchmarking can warn radiologists, who are using multiple scan protocols, when the median CTDIvol is too high or can inform those using a restricted number of scan protocols when patients could benefit from a more tailored lower dose protocol.
Full toxicologic profiles of chemical mixtures, including dose-response extrapolations to realistic exposures, is a prohibitive analytical problem, even for a restricted class of chemicals.
Detailed dose-response analysis revealed that absence of CD40 reduced NGF-promoted neurite growth over a restricted range of low NGF concentrations.
"It's a restricted market.
Kindl, 26, was a restricted free agent.
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CEO of Professional Science Editing for Scientists @ prosciediting.com