Additionally, three transcripts encoding heme oxygenase 1 (hmox1) were differentially-regulated by LG and MR. These proteins have roles as cellular anti-oxidants and in the maintenance of cellular redox balance, and have previously been shown to be amongst the most responsive markers of cellular oxidative stress [ 48, 49].
The magnitude of these responses was greatest with CYP26B1, demonstrating that CYP26 is a more responsive marker.
sCD25 does not, however, appear to be a highly responsive marker in patients with moderate disease or mild flare.
Take Motion Capture, whereby an actor, draped with a network of responsive markers along the body, performs a series of choreographed movements, which are plotted on a computer and then laminated with layers of additional detail.
Immobilization stress also induced a rapid increase in the level of Per1 mRNA, as a stress-responsive marker, but not in that of Per2 in mouse peripheral tissues (heart, liver and kidney) [24].
The intersect between query and reference signatures (genes driving the similarity score, see Material and Methods) consisted of known dehydration responsive marker genes, namely DREB family genes, including DREB-1A (At4g25480), DREB-2A (At5g05410), DREB-1C (andg25470), anDREBEB 1B (At4g25490), [see Additional file 4].
RD29b is an ABA-responsive marker gene in the SnRK2s pathway, and is induced by abiotic stress [ 29, 41].
In their clinical study, since Spry4 levels were dramatically decreased in patients responsive to the drug compared with non-responsive patients, the authors proposed Spry4 as a reliable marker of the imatinib-responsive treatment.
In addition, the green module eigengene significantly correlated with the expression of heat responsive markers genes At5g59720 (Pearson cor = 0.95, p = 10 × 10-20) At4g369906990 (Pearson cor = 0.78, p = 4.6 × 10-14) as previously reported [ 32- 34].
Yoshimoto et al. have demonstrated that levels of the phytohormone SA increased along with transcripts of senescence-associated SAG12 and of the SA responsive markers PR1 and PR2 in atg mutants.
