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A fully proficient DDR cell activates a response to overcome the difficulties imposed by spontaneously arising and genotoxin-induced delayed or stalled DNA replication forks.
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Like transaminases, ALP activity was also reduced during recovery phase as a compensatory response to overcome the stress.
HF is characterized by chronic activation of neuro-hormonal pathways representing a compensatory response to overcome depressed cardiac function.
Further work is needed to clarify which transcriptome alterations observed reflect a specific response to overcome artesunate toxicity or more general perturbations on the path to cellular death.
One mechanism of PI resistance relates to the increased expression of proteasome subunits as a primary response to overcome PI targeting.
Autophagy was transiently activated only in PNT1a cells between 6 and 12 h of treatment as a survival response to overcome Polyphenon E-induced ER stress [ 47].
The induction of MT by arsenicals can be envisioned, at least in part, as an adaptive response to overcome toxic insult from this metalloid.
Furthermore, the existence the phage-borne polysaccharide depolymerase [ 28, 29] suggests that such enzyme is an evolutionary response to overcome the obstacle posed by the exopolysaccharide, the main scaffold of the biofilm (equivalent to the top agar gel in our study).
The abnormal and disproportionate growth of choroidal vessels associated with wet AMD likely stems from a compensatory angiogenic response to overcome an earlier phase of microvessel degeneration and reinstate metabolic equilibrium to the hypoxic macula.
We have explored the possibility of active transport of G-actin by myosin motors, which would be an expected biological response to overcome the limitation of a diffusion-based process.
(2) Such increase possibly represents a physiologic adaptive response to overcome the increased placental vascular resistance and to minimize platelet and leukocyte adhesion to the surface of placental villi or within the intervillous spaces.
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CEO of Professional Science Editing for Scientists @ prosciediting.com