In summary, p53 exerted a repressive effect on expression levels of the SIRT1-ΔExon8 protein, consistent with p53-dependent repression of SIRT1-ΔExon8 mRNA levels (see above).
The high carbon dioxide content also has a repressive effect on yeast growth.
Marcoleta et al. (2011) demonstrated that ethanol addition promoted carotenogenesis in the yeast Xanthophyllomyces dendrorhous by increasing the expression levels of key genes, whereas glucose exerted a repressive effect.
These genetic data supported a repressive effect of Cno on Ras-MAPK signaling.
Recently, PGF2α was proposed to exert a repressive effect on testosterone release by testis Leydig cells [37], [38].
This result suggests that Sp-DN prevents the binding of Sp factor having a repressive effect on REST promoter.
Hence, a repressive effect must be present to prevent UI from driving the expression beyond specification level.
Then we transfected CNE cells with miR-15b and miR-16, and found that miR-15b and miR-16 did not have a repressive effect on PTN expression.
This implies that Otx and R sites operate together to introduce a repressive effect on gene expression such that the state cannot achieve differentiation level.
Indeed, rather than being activated, RTN1* may be stabilized by another binding protein that would prevent miR-195 from binding to RTN1* to exert a repressive effect.
In fact, apart from earlier (0 25 pfh) activation, Otx exhibits a repressive effect at the period of 40 50 pfh when R is activated.
