The phrase "a replication stage" is correct and usable in written English.
It can be used in contexts related to processes, experiments, or methodologies where replication is a key component, such as in scientific research or project development.
Example: "During the experiment, we will enter a replication stage to ensure the results are consistent and reliable."
Alternatives: "a duplication phase" or "a reproduction step".
A total of 554 men from the Korean Cancer Prevention Study-II were used as a discovery stage and 1575 men collected by the Korean Genome Epidemiology Study were used as a replication stage.
Upholding the gold standard in association studies, all five genome-wide association scans included a replication stage, where the robustness of identified associations was tested.
Replication data-sets are ideally larger than the initial data-set, since effects sizes are generally smaller at a replication stage.
This study was carried out in two stages: an initial screening stage and a replication stage that verifies the associations of the significant SNPs emerged from the screening.
If allelotyping is part of a multi-stage design combined with a screening stage by individual genotyping and a replication stage, the cost savings that can be achieved by the pooling approach depend on several factors like the number of pool replicates, the genetic effect sizes that are present and on the costs per genotype compared to individual genotyping.
Analyses were based on data from the iCOGS array, a custom array comprising ∼200 000 SNPs designed to study susceptibility to prostate (PRACTICAL Consortium), breast and ovarian cancers (12), together with data from a UK GWAS study (Stage 1) and subsequent custom array designed as a replication stage of the Stage 1 GWAS that was genotyped in studies from the UK and Australia (Stage 2).
Finally, we took advantage of the availability of the Autism Genetic Resource Exchange AGREE) dataset, and tested, in a third replication stage, whether SNPs found to be associated with autistic-like traits in the general population were also associated with diagnosed ASD.
Mechanistically, Inoviridae might be more prone to such co-infection due to their long infection cycle whereby they extrude their filamentous virions without killing their host (Rakonjac et al., 2011), with a dsDNA replication stage (Salim et al., 2008) that could increase genomic exchanges with co-infecting dsDNA viruses.
Based on their transcriptome profiles and lack of virus in anterior kidney, it is unlikely that the IHNV carrier fish represents an acute replication stage.
We assume a design consisting of a genomewide association scan (stage 1) followed by a replication study (stage 2) in which only SNPs meeting some selection criteria in stage 1 are of interest.
For the replication stage, a new set of samples were collected: 7 postmenopausal women with osteoporotic fracture and 6 with osteoarthritis in the absence of osteoporosis (according to BMD and T-score measurements [mean ± SD]: 0.882 ± 0.158 and - 0.342 ± 1.622, respectively).
